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Mi et al., 2005
They are also found in retinal pigmented and colonic epithelial cells, keratinocytes, breast cells, microglia, and possibly at low levels in the liver (18)
NICE recommends these agents particularly for patients with established cardiovascular disease, heart failure, or chronic kidney disease
Mechanisms such as accelerated cell turnover or altered gut microbiota composition caused by GLP-1 RA use may be part of the elevated risk observed in the context of colorectal cancer
Using anything else is an unnecessary risk
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